My problem with Thing-Thing 3 was that the enemies were respwaning and shooting at you from way outside the screen boundaries - no such problem here, since the game takes place in cramped rooms with no cover, so it's like shooting fish in a barrel, and you're the fish. Your best defence is to kill enemies before they kill you, which is hard considering they shrug off headshots from assault rifles like it's nothing. You fight around five enemies at a time, they can kill you in less than a second if you're unlucky, all while you must kill up to 80 of them to progress to the next area. Yeah, you have fast health regeneration, yeah, the checkpoints are frequent, but the game as a whole is frustrating and is not fun, and I think only now do I have the hardware to run it without too much slowdowns.
Also it contains the biggest "Fuck You" ending imaginable