I made a version of "The lady with an ermine" where it is actually Serena from pokemon with her eevee. I worked with water colours and tempera on thick paper. I layed down some guide lines to put everything in the place as it is in the original. Then I tried to "pimp it up" as much as possible but not getting too crazy. I added the background to give it colourful feeling ( like it's a pokemon world) where original has a black background to push out the face, so I tried to push out some elements with the background. As the clothing is black so the colours surrounding it should be brighter and the ones around the face should be darker. I still tried to keep it as realistic looking as possible.

Original painting: https://www.wikiart.org/en/leonardo-da-vinci/the-lady-with-the-ermine-cecilia-gallerani-1496

mid development photos: https://imgur.com/a/StQnT