The All Tomorrows / The Simpsons crossover couch gag you never knew you needed.

Although I think Marge would make a great Pterosapien, I decided to only pick beings from the "Man Extinguished" era for this (i.e. with the Qu invading and then leaving). With the possible exception of Homer -- Bone Crushers are said to have evolved from Qu-creations, but they're included alongside the other Qu-created post-human species in that chapter of All Tomorrows, so there may be some overlap.

Starring:

Homer as a Bone Crusher

Marge as a Temptor

Lisa as a Spacer

Bart as a Hedonist

Maggie as a Qu

Martin, Nelson, Otto, Kearney, Apu, Snake, Carl, Lenny, Mr. Burns, Wendell, Dr. Hibbert, Barney, Mindy, Bumblebee Man, Moe, Ned, Willie, Akira, Milhouse, Moleman, Krusty, Sherri, Terri, Agnes, Comic Book Guy, Seymour, and some other randos as Colonials.