I love this! :D It has a Mario & Luigi feel to it.
The panning and the way it's mixed is cool too. Definitely a breath of fresh air compared to some of the other chiptune songs I've heard.
Not sure about the skeleton guitar. Are you talking about that melodic synth from about half-way through? It's cool sounding. I do think that as a song the ending is abrupt. I wish it was posted as a loop. I'm looping right now and it sounds great! Although, the aesthetic of the song gradually gets busier towards the end, so hearing it looped in its entirety is a bit jarring every time it restarts.
Still, nice work!
More info about how I review music here: https://codefreq.newgrounds.com/news/post/1089806