In RE4, when Luis is stabbed through the chest from the back. I really wanted that antidote too.
In Gun when you meet the preacher for the second time, he slits Jenny's throat followed by you having a bottle cracked over your head.
In Tales of Symphonia, You enter one of the last fortresses and all you firends which spent money on and spent time leveling up the entire game start dieing one by one.
That one time in Tony Hawk when I had a 5,000,000 point combo going before ending it in a faceplant.
When Chrono died in Chrono Trigger. I was like, "HE CAN'T DIE! HE'S IN THE FUCKING TITLE!"
In Beyond Good and Evil, after getting the second flight stabilizer, you return to the lighthouse, and all the kids have been kidnapped and the Alpha Sections destroyed your entire island. That is one sad scene.
"Anything coming must automatically give way to your perfection, your anger, your awesomeness. The world must yield." -- Best Fortune Cookie Ever ; -[AXP]-