Excellent
That was by far one of the best storied submissions i've ever seen on Newgrounds. It sort of reminded me of the movies "Kill Bill" and "The Beach." You've definatly got potential in the directing business, just keep at it and look for bigger things.
Now for the Film.
I thought this was just great, you chose a great story for a great game, and you made it all tie together. I've never seen such personality in a sprite film like you've put into this. I took the time to watch the intro to this too, and it too tied into the movie, it was very well directed. I especially like the fight scene. It was very video game-esque. The movie kept me on the edge of my seat. I especially liked how you didn't make "Little Mac" some super fighter after prison, you made it look like he lost his talent as a fighter, it was magnificent. I found no major flaws in this, even the sprites you made looked very real. I liked the comic relief you had the the Duck-Hunt cameo, and I liked how you tied Duck-Hunt into the movie too.
All in all, this was an excellent film. By far one of my favorites on NewGrounds. Keep up the spectacular work. And I cannot wait till fall when I can see more of this.
P.S. Seriously look into directing actual movies, because I think you could do really good.